JCCT 167

Shingles (also known as herpes zoster) is a painful skin rash caused by varicella zoster virus (VZV), the virus that causes chickenpox. Shingles can develop in people years after they had chickenpox. Around 1 in 3 people will develop shingles during their lifetime. The risk of developing shingles is highest in older adults.

Although there are licensed vaccines available to help prevent shingles, these vaccines may have some limitations. For example, some of the licensed vaccines may not be widely available in some countries or may have more side effects than seen with other vaccines that are given to adults.

The purpose of this study is to see if a new type of investigational VZV vaccine, called Varicella Zoster Virus modRNA Vaccine (VZV modRNA vaccine), is safe and can prompt the body to produce antibodies which may help prevent shingles. The term “investigational vaccine” means that it has not yet been approved by health authorities. As VZV modRNA vaccine is an investigational vaccine, we need to test 3 different candidates or versions of VZV modRNA vaccine to find out which candidate, dose level (strength) and dosing schedule will work best. The safety and tolerability information about the vaccine used in this study, meaning the type and frequency of any possible side effects, will be collected and evaluated throughout the study.

JCCT 157

The purpose of this study is to collect blood (serum) or plasma from healthy people who have not been exposed to N. meningitides bacteria and do not have antibodies to the bacteria. Plasma and serum are the liquid parts of blood (that is, blood without the cells in it). The main difference between plasma and serum is that plasma has proteins that help blood clot, and serum does not. An antibody is a substance made by the immune system to fight infection. Both serum and plasma contain important components called complement proteins. These proteins together with the antibody are important for the immunity against infection-causing bacteria.

This study aims to collect blood (serum) or plasma that has suitable complement from donors for use in laboratory tests to measure antibody responses of subjects participating in studies where vaccines against N. meningitidis are administered. It’s hard to find donors who have human complement that can be used for these tests. Many adults have been exposed to N. meningitidis and already have antibodies in their blood, which prevent them from being eligible to donate plasma or blood (serum) for this study.

JCCT 179


Coronaviruses are a large family of viruses that cause illness ranging from the common cold to more severe diseases, such as Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS). Coronaviruses are zoonotic, meaning they are transmitted between animals and people.

An outbreak of the coronavirus disease (COVID-19) caused by the 2019 novel coronavirus SARS-CoV-2 began in Wuhan, Hubei Province, China in December 2019 and has spread throughout China and to over 215 other countries, territories, and areas, including the United States.

Vaccines serve to prepare your immune system for fighting illnesses. Certain cells of the immune system produce antibodies (special proteins) that recognize viruses and other pathogens (things that cause disease) and prevent them from causing illness. Currently, there are several vaccines that have been authorized or approved for the prevention of COVID-19 disease. However, as new strains of the virus